Blue pseudochromhidrosis secondary to topiramate treatment.

© 2009 The Authors. doi: 10.2340/00015555-0696 Journal Compilation © 2009 Acta Dermato-Venereologica. ISSN 0001-5555 Sir, Topiramate (TPR) is an adjunctive treatment for patients with refractory epilepsy. Several cases of hypohidrosis under TPR treatment have been reported. We describe here a new reversible side-effect on human sweating function: blue pseudochromhidrosis. Chromhidrosis and pseudochromhidrosis are rare skin disorders. Chromhidrosis refers to the excretion by the apocrine glands of sweat containing lipofuscin pigments, while the terms of pseudochromhidrosis or extrinsic chromhidrosis are used when the eccrine sweat is coloured on the surface of the skin as a result of the deposit of extrinsic dyes or paints, or by the transformation by chromogenic bacteria.